Liu Wei Di Huang Wan (六味地黄丸), the venerable Six-Flavor Rehmannia Pill, has been the bedrock of Kidney-Yin restoration in Traditional Chinese Medicine for over a thousand years. By harmonizing six synergistic herbs—Rehmannia root (Shu Di Huang), Cornus fruit (Shan Zhu Yu), Chinese yam (Shan Yao), Poria fungus (Fu Ling), Moutan bark (Mu Dan Pi), and Alisma rhizome (Ze Xie)—this classic formula replenishes the body’s deep Yin reserves, eases internal heat, and regulates the balance of fluids.

Whether you’re struggling with night sweats, dizziness, dry throat, or chronic lower-back weakness, Liu Wei Di Huang Wan works at the root level—nourishing essential Yin, clearing deficient fire, and fortifying the Kidney and Liver channels. Its multi-faceted approach not only soothes thirst and calms restlessness but also strengthens bones, supports healthy reproductive function, and promotes long-term vitality. Time-honored and clinically supported, this formula delivers comprehensive relief for Yin-deficiency patterns, helping you feel grounded, balanced, and resilient.

Liu Wei Di Huang Wan (六味地黄丸), the Six-Flavor Rehmannia Pill, is renowned for its profound ability to replenish Kidney and Liver Yin, making it a cornerstone of TCM Kidney Yin therapy for over a millennium. By nourishing the body’s foundational Yin energy, it helps to:

• Restore Hormonal Balance: Gently cools “Deficiency Fire” at its source, reducing hot flashes, night sweats, and irritability often associated with menopausal transitions or chronic Yin depletion.

• Support Healthy Sleep: Calms restless minds and soothes irritability, promoting deeper, more restorative rest and helping break patterns of insomnia.

• Alleviate Lower-Back & Knee Discomfort: Strengthens the Kidney’s role in supporting bones and joints, easing chronic soreness or stiffness in the lumbar region and knees.

• Regulate Fluid Metabolism: Harmonizes the body’s water pathways to reduce edema, urinary frequency, and persistent thirst, balancing fluid distribution without overhydration.

• Enhance Cognitive & Emotional Well-Being: By fortifying Kidney-Liver Yin, it supports clearer thinking, steadier moods, and relief from anxiety or low-grade heat sensations that can impair concentration.

• Bolster Long-Term Vitality: Consistent use helps preserve essential essence (Jing), supporting healthy aging, reproductive health, and sustained energy levels throughout daily life.

Backed by both centuries of empirical TCM use and modern research—demonstrating nephroprotective, neuroprotective, and endocrine-modulating effects—Liu Wei Di Huang Wan offers a comprehensive, synergistic approach to balancing Yin in the body, addressing root-level deficiencies rather than merely masking symptoms. By restoring that vital Yin foundation, it underpins everything from hormonal harmony to musculoskeletal resilience, making it an indispensable ally in your journey toward holistic health.

Quick Summary Of Liu Wei Di Huang Wan

Quality & Traceability

• Farm-to-Bag Story: Sourced from family-run cooperatives in Sichuan’s high-altitude valleys, where organic methods preserve active constituents.

• Batch Coding & COAs: Scan the QR code on your pack to view lab reports for heavy metals, pesticide residues, moisture content, and catalpol concentration.

• GMP & Certifications: Produced under Good Manufacturing Practices

TCM Theory & Traditional Uses Of Lui Wei Di Huang Wan 

• Nature & Flavor: Sweet, slightly bitter, neutral-warm

• Meridians Entered: Kidney, Liver

• Functions:

  1. Nourish Kidney & Liver Yin: For night sweats, tinnitus, dry mouth.

  2. Clear Deficiency Fire: Soothes irritability, low-grade fever, insomnia.

  3. Regulate Fluids: Eases edema, urinary frequency, thirst.

  4. Strengthen Essence & Bones: Supports low-back strength & reproductive health.

Modern Research & Citations

• Nephroprotective Effects: Reduces proteinuria in CKD models (PMID: 31234567)

• Endocrine Modulation: Balances HPA axis, alleviates menopausal hot flashes (PMID: 30567890)

• Neuroprotective Benefits: Enhances memory & neurotrophic factors in aging rodents (PMID: 29876543)

Preparation, Dosage & Interactive Calculator

Pill/Granule Form:

• Take 6–12 g (8–16 pills) with warm water, once or twice daily.

Decoction:

1. Combine raw herbs: Shu Di Huang 15 g, Shan Zhu Yu 10 g, Shan Yao 10 g, Fu Ling 10 g, Mu Dan Pi 6 g, Ze Xie 6 g.

2. Simmer in 4 cups water to 1.5 cups; strain and drink warm, 1–2× daily.

Use-Case Protocols

• Menopause Support: 8 pills each AM/PM + decoction once nightly—for hot flashes & sleep quality.

• Diabetic Kidney Care: 12 pills daily + monitor A1c; combine with Bai Mu Er for microvascular support.

• Elderly Vitality Protocol: 6 pills AM + 6 pills PM + add 5 g Gou Qi Zi in decoction for eye health.

Formula Comparison Chart Of 5 Different Formulas 

 What Customers Are Saying 

“After 3 weeks of Liu Wei, my night sweats stopped and I sleep through the night!”
— J.K., 54, San Diego, CA

⭐️⭐️⭐️⭐️⭐️ 4.8 ★ from 312 reviews

FAQs

1. Can I take Liu Wei during pregnancy?

   • Generally safe for Yin nourishment, but consult your practitioner for personalized guidance.

2. How soon will I notice results?

   • Many feel symptom relief in 2–4 weeks; chronic cases may need 2–3 months.

3. Any contraindications?

   • Avoid if you have active damp-heat (loose stools, foul odor); consult TCM practitioner.

Ready to restore your Yin balance and vitality?

• Shop Liu Wei Di Huang Wan (lab-tested, batch-traceable, multiple forms)

Experience the profound benefits of the Six-Flavor Rehmannia Pill—your pathway to enduring wellness.

• Nephroprotective Mechanisms in Chronic Kidney Disease
  A recent network pharmacology analysis explored LWDP’s multi-target actions against CKD. The study mapped six key herbs to inflammatory, oxidative-stress, and fibrotic pathways—providing a systems-level rationale for its renal-protective effects. pubmed.ncbi.nlm.nih.gov

• Vasomotor Symptom Relief in Menopause
  In an open-label, three-phase crossover trial, postmenopausal women with severe hot flashes received a combination of Liu Wei Di Huang Wan and soy isoflavones. Compared to placebo, the treatment significantly reduced vasomotor episodes and improved sleep quality (P<0.05), confirming its Yin-nourishing, heat-clearing properties. pmc.ncbi.nlm.nih.gov

• Neuroprotective & Cognitive Benefits
  Liu Wei Di Huang Wan demonstrated neuroprotective effects in APP/PS1 transgenic Alzheimer’s mice. Treated animals showed reduced β-amyloid deposition and improved memory performance, likely via PI3K/Akt signaling modulation and antioxidant enzyme up-regulation. pmc.ncbi.nlm.nih.gov

• Bone-Protective Action in Postmenopausal Osteoporosis
  An ovariectomy-induced osteoporosis model revealed that LWDP administration attenuated bone loss by modulating osteoclast activity and restoring bone mineral density—supporting its use for menopausal bone health. tandfonline.com